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Veliparib dihydrochloride

CAS No. 912445-05-7

Veliparib dihydrochloride( ABT-888 dihydrochloride | ABT888 dihydrochloride | ABT 888 dihydrochloride )

Catalog No. M16549 CAS No. 912445-05-7

Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Veliparib dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.
  • Description
    Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively; displays no activity against SIRT2 and selective biochemical profile in a panel of 74 receptor-binding assays; strongly potentiates temozolomide in the B16F10 s.c. murine melanoma model, also potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models. Breast Cancer Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ABT-888 dihydrochloride | ABT888 dihydrochloride | ABT 888 dihydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP1|PARP2
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    912445-05-7
  • Formula Weight
    317.2142
  • Molecular Formula
    C13H18Cl2N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 3.2 mg/mL
  • SMILES
    C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl
  • Chemical Name
    1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Donawho CK, et al. Clin Cancer Res. 2007 May 1;13(9):2728-37. 2. Albert JM, et al. Clin Cancer Res. 2007 May 15;13(10):3033-42. 3. Liu X, et al. Mol Cancer Res. 2008 Oct;6(10):1621-9. 4. Palma JP, et al. Anticancer Res. 2008 Sep-Oct;28(5A):2625-35.
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